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Emeset.
   Tablets/Injections Structure.

Emeset-4 Tablets = Ondansetron Hydrochloride Dihydrate equivalent to Ondansetron 4mg
Emeset-8 Tablets = Ondansetron Hydrochloride Dihydrate equivalent to Ondansetron 8mg
Emeset 2 ml Injection 2 ml ampoule = Ondansetron Hydrochloride Dihydrate Equivalent to Ondansetron 4mg and water for injection IP q.s.
Emeset 4 ml Injection 4 ml ampoule = Ondansetron Hydrochloride Dihydrate Equivalent to Ondansetron 8mg and water for injection IP q.s.

   Usage.

Emeset is used for management of a nausea and vomitting caused cytotoxic chemotherapy and radiotheraphy, and for prevention and treatment post-operative nauseas and tearing (PONV).

   Recommended dosage.

Chemotherapy of a cancer and radiotheraphy

Adults

Highly Emetogenic Chemotherapy

Day 1 Days 2 - 5

Unique dosage of 8 mg a slow intravenous injection immediately before chemotherapy of 8 mg orally twice daily for till 5 days or dosage of 8 mg slow intravenous

Injection immediately before

The chemotherapy, accompanied two further intravenous dosages of 8 mg two - four hours separately, or constant injection from 1 mg / hour for till 24 o'clock 8 mg orally twice daily for till 5 days or unique dosage of 32 mg dissolved in 50-100 ml of saline soil or another the compatible liquid of injection also installed within not less than 15 minutes immediately before chemotherapy of 8 mg orally twice daily for about five days

Emetogenic Chemotherapy/Radiotherapy

Day 1 Days 2 - 5

Unique dosage of controlled 8 mg as a slow intravenous injection immediately before chemotherapy / radiotheraphy of 8 mg orally twice daily for till 5 days or 8 mg orally, 1-2 hours vefore chemotherapy / the radiotheraphy followed on 8 mg orally 12 hourly 8 mg orally twice daily for till 5 days

Children

Emetogenic Chemotherapy/Radiotherapy

Day 1 Days 2 - 5

Unique intravenous dosage 5mg/m2 immediately before chemotherapy accompanied on 4 mg orally 12 hours after 4 mg orally twice daily for till 5 days

* In both, adult and children, in high emetogenic chemotherapy, efficiency ondansetron in the first 24 hours can be increased addition of a unique intravenous dosage phosphate of sodium of dexamethasone on 20 mg up to chemotherapy

Elderly and in kidney function to which harm, any change of a dosage, frequency of a dosage or route of administration not required in patients more than 65 years or with kidney deterioration.

In function hepatic to which harm, in patients with moderate or serious deterioration hepatic, a full daily dosage from 8 mg should not be exceeded.

Post-operative Nausea and Vomiting (PONV)

DOSAGE

For prevention post-operative nauseas and tearing 8 mg, the data orally one hour before the anesthesia, 8 mg accompanied with two further dosages in eight-hourly intervals or unique dosage of pure 4 mg given by a slow intravenous injection in an induction of anesthesia for treatment established post-operative nauseas and vomittings a unique dosage of the pure{clean} 4 mg given by a slow intravenous injection

Pediatric use

There is no experience in use ondansetron in prevention and treatment post-operative nauseas and tearing in children.

In elderly

There experience in use ondansetron in prevention is limited both treatment post-operative nauseas and tearing in elderly.

In kidney function to which harm, any change of a daily dosage or frequency of a somnolence, or route the administration is required.

In function hepatic to which harm, carrying out of calculations ondansetron is considerably reduced and half-life wheys considerably long in subjects with moderate or serious deterioration function hepatic. In such patients the full daily dosage of 8 mg should not be exceeded.

Compatibility with intravenous liquids

According to good pharmaceutical practice, intravenous decisions should be it is ready during injection with the following recommended injection decisions:
- Chloride of sodium intravenous IP injections of 0.9 % w/v
- Dextrose intravenous IP injections of 5 % w/v
- Mannitol intravenous IP injections of 10 % w/v
- Intravenous decision of Ringers
- Potassium chloride of 0.3 % w/v and glucose of 5 % w/v

   Warnings and Precautions.

Hypersensitivity to any component of drug.

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