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Emeset.
| Tablets/Injections Structure. |
Emeset-4 Tablets = Ondansetron Hydrochloride Dihydrate equivalent to Ondansetron 4mg
Emeset-8 Tablets = Ondansetron Hydrochloride Dihydrate equivalent to Ondansetron 8mg
Emeset 2 ml Injection 2 ml ampoule = Ondansetron Hydrochloride Dihydrate Equivalent to Ondansetron 4mg and water for injection IP q.s.
Emeset 4 ml Injection 4 ml ampoule = Ondansetron Hydrochloride Dihydrate Equivalent to Ondansetron 8mg and water for injection IP q.s.
Emeset is used for management of a nausea and vomitting caused
cytotoxic chemotherapy and radiotheraphy, and for prevention and
treatment post-operative nauseas and tearing (PONV).
Chemotherapy of a cancer and radiotheraphy
Adults
Highly Emetogenic Chemotherapy
Day 1 Days 2 - 5
Unique dosage of 8 mg a slow intravenous injection immediately before chemotherapy of 8 mg orally twice daily for till 5 days
or dosage of 8 mg slow intravenous
Injection immediately before
The chemotherapy, accompanied two further
intravenous dosages of 8 mg two - four
hours separately, or constant injection
from 1 mg / hour for till 24 o'clock 8 mg orally twice daily for till 5 days
or
unique dosage of 32 mg dissolved in
50-100 ml of saline soil or another
the compatible liquid of injection also installed
within not less than 15 minutes
immediately before chemotherapy of 8 mg orally twice daily for about five days
Emetogenic Chemotherapy/Radiotherapy
Day 1 Days 2 - 5
Unique dosage of controlled 8 mg
as a slow intravenous injection
immediately before chemotherapy /
radiotheraphy of 8 mg orally twice daily for till 5 days
or
8 mg orally, 1-2 hours
vefore chemotherapy /
the radiotheraphy followed
on 8 mg orally 12 hourly 8 mg orally twice daily for till 5 days
Children
Emetogenic Chemotherapy/Radiotherapy
Day 1 Days 2 - 5
Unique intravenous dosage 5mg/m2 immediately before chemotherapy
accompanied on 4 mg orally
12 hours after 4 mg orally twice daily for till 5 days
* In both, adult and children, in high emetogenic chemotherapy, efficiency ondansetron
in the first 24 hours can be increased addition of a unique intravenous dosage
phosphate of sodium of dexamethasone on 20 mg up to chemotherapy
Elderly and in kidney function to which harm,
any change of a dosage, frequency of a dosage or route of administration not
required in patients more than 65 years or with kidney deterioration.
In function hepatic to which harm,
in patients with moderate or serious deterioration hepatic, a full daily dosage
from 8 mg should not be exceeded.
Post-operative Nausea and Vomiting (PONV)
DOSAGE
For prevention post-operative nauseas and tearing 8 mg, the data orally one hour before the anesthesia, 8 mg accompanied with two further dosages in eight-hourly intervals
or
unique dosage of pure 4 mg
given by a slow intravenous injection
in an induction of anesthesia
for treatment established post-operative nauseas and vomittings a unique dosage of the pure{clean} 4 mg given by a slow intravenous injection
Pediatric use
There is no experience in use ondansetron in prevention and
treatment post-operative nauseas and tearing in children.
In elderly
There experience in use ondansetron in prevention is limited
both treatment post-operative nauseas and tearing in elderly.
In kidney function to which harm,
any change of a daily dosage or frequency of a somnolence, or route
the administration is required.
In function hepatic to which harm,
carrying out of calculations ondansetron is considerably reduced and half-life wheys
considerably long in subjects with moderate or serious deterioration
function hepatic. In such patients the full daily dosage of 8 mg should not be
exceeded.
Compatibility with intravenous liquids
According to good pharmaceutical practice, intravenous decisions should
be it is ready during injection with the following recommended injection
decisions:
- Chloride of sodium intravenous IP injections of 0.9 % w/v
- Dextrose intravenous IP injections of 5 % w/v
- Mannitol intravenous IP injections of 10 % w/v
- Intravenous decision of Ringers
- Potassium chloride of 0.3 % w/v and glucose of 5 % w/v
| Warnings and Precautions. |
Hypersensitivity to any component of drug.
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