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Glumet.
   Tablets Structure.

Glumet-500 = Metformin Hydrochloride IP 500mg

   Usage.

Diabetes of the dependent non-insulin when the diet suffered failure and it is especial if the patient is corpulent. Glumet is possible to give one as addition to sit on a diet or can be controlled in a combination with sulphonylurea.
Glumet it can be used also for management PCOS (polycystic ovarian syndrome) attributes.

   Recommended dosage.

The dosage metformin should be individualized on the basis of both efficiency and tolerance, not exceeding a maximum recommended daily dosage of 2500 mg. Metformin should be handed over divided dosages with food also should be started in a low dosage, with a gradual dosage rise both to reduce gastrointestinal by-effects and to allow identification of the minimal dosage required for the adequate control glycaemic from the patient.

Usual starting dosage metformin tablets on 500 mg - one tablet b.i.d., given with morning and evening food. Increases in a dosage should be made in increments of one tablet every week, given in the divided dosages, up to maximum of 2500 mg day.

Transfer from other antidiabetic therapy

By transfer of patients from standard oral hypoglycemic agents another than chlorpropamide to metformin, any period of transition at all necessary. By transfer of patients from chlorpropamide, the care should be it is carried out within first two weeks because of long detention from chlorpropamide in a body, conducting to an imposed drug makes and possible hypoglycemia.

Accompanying circumstance metformin and oral sulphonylurea therapy if patients have not answered four weeks of the maximal dosage metformin monotherapy, consideration it is necessary to give gradual addition from oral sulfonylurea at continuation metformin in a maximal dosage, rven if previous primary or secondary refusal to sulfonylurea has taken place.
With accompanying circumstance metformin and sulfonylurea therapy, the desirable control from glucose of blood can be received, adjusting a dosage of each drug. however, attempts should be made to identify the minimal effective dosage from each drug to reach this purpose. With therapy of accompanying circumstance, risk hypoglycemia connected with sulfonylurea therapy proceeds and can be increased. Corresponding precautions should be taken.
If patients well have not answered one - three months therapy of accompanying circumstance with the maximal dosage metformin and a minimum dosage oral sulfonylurea, establishment of therapy of insulin and the termination from these oral agents it is necessary to consider.
In PCOS, 1.5 by 2.55 grammes / days in the divided dosages within 8-12 weeks (can be also used everywhere on pregnancy in cases PCOS with pregnancy).

   Warnings and Precautions.

- Acidemia, the Sharp heart attack of a myocardium, Feeding by a breast, Cardiogenic shock, Diabetic ketoacidosis, Hepatic disease, Hypoxia, Lactic acidosis/Metabolic acidosis, Renal refusal, the Sepsis, Surgery, educate contrast administration

- To not use metformin in patients who knew metformin Hypersensitivity

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