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Pletoz.
   Tablets Structure.

Pletoz-50 = cilostazol 50mg
Pletoz-100 = cilostazol 100mg

   Usage.

Cilostazol is designated for reduction of attributes of an alternating fever lameness.

   Recommended dosage.

Recommended dosage cilostazol - 100 mg b.i.d. taken {undertaken} at least half for one hour before or after two hours after a breakfast and a dinner. A dose of 50 mg b.i.d. It is necessary to consider during coadministration such inhibitors CYP3A4 as ketoconazole, itraconazole, erythromycin and diltiazem, and during coadministration such inhibitors CYP2C19 as omeprazole.

Patients can already answer later 2 - 4 weeks after initiation of therapy, but treatment for till 12 weeks can be necessary before favourable effect it is tested.

The termination of therapy

The accessible data suggest, that the dosage cilostazol can be reduced or stopped without again bound (that is platelet hyperaggregability).

   Warnings and Precautions.

Cilostazol and a little from it metabolites are inhibitors phosphodiesterase III. Some medicines with this pharmacological effect have caused reduced survival in comparison with placebo in patients with class III-IV close heart refusal. Cilostazol is served by contra-indication in patients with close cardiac arrest from any gravity.

Cilostazol is served by contra-indication in patients with known or suspected hypersensitivity to a drug.

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