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Stavir.
   Capsules Structure.

Stavir-30 = Stavudine 30mg
Stavir-40 = Stavudine 40mg

   Usage.

Stavir is designated for treatment of the INFECTED HIV of patients as a part therapy of a combination.

   Recommended dosage.

Adults: an interval between oral doses should be 12 hours. Stavudine can be taken without the attitude to food. A recommended starting dose it is based on weight of a body as follows:
40 mg twice daily for patients> 60 kg
30 mg twice daily for patients <60 kg

Paediatrics: a recommended starting dose for pediatric patients weighing is less than 30 kg - 1 mg / kg/day, given than each 12 hours. Pediatric the patients weighing of 30 kg or should accept the recommended adult more dose.

Regulation of a dosage: Patients should be checked up for development peripheral neuropathy. Attributes can solve, whether therapy is taken away quickly. In some cases, attributes can worsen temporarily after the termination of therapy. If attributes decide completely, renewal treatment can be considered in half of dose.

Renal Deterioration

Stavudine can cope to adult patients with harming renal function. The following schedule is recommended:

Carrying out of calculations the Creatinines (ml / minute), recommended Stavudine the dose in patient weight

> 60 kg <60 kg
> 50 40 mg each 12 hours of 30 mg each 12 hours
26-50 20 mg each 12 hours of 15 mg each 12 hours
10-25 20 mg each 24 hours of 15 mg each 24 hours

Paediatrics: there are insufficient data to recommend the certain dose regulation stavudine in children with renal deterioration. Reduction the dose and-or increase in an interval between doses should beconsidered.

Hemodialysis Patients

Recommended dose - 20 mg each 24 hours (> 60 kg) or 15 mg everyone 24 hours (<60 kg), controlled after end hemodialysis and at the same time day on non-dialysis hours.

   Warnings and Precautions.

Stavir is served by contra-indication in patients with clinically essential hypersensitivity to stavudine or to any of the components containing in the formulation.

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